Project Description

Thymalinum

(lyophilized powder to prepare solution for injections)

international nonproprietary name

Not established

Ref

BP-0145

Pharmacotherapeutic group

Immunomodulator and biostimulant.

Composition of the preparation

A bottle contains 10 mg of Thymalinum.

Pharmacological action

Pharmacodynamics

Thymalinum stimulates cellular immunity (regulates the quantity and correlation of T- and B-lymphocytes, stimulates reactions of cellular immunity), increases phagocytosis, processes of regeneration and hemopoiesis in case of their depression.

Pharmacokinetics

There is no detailed description. Effective in parenteral use. When using perorally, it is inactivated in gastrointestinal tract quickly.

Indications 

The drug is prescribed for the treatment of bronchitis, pneumonia, pleurisy, subacute bacterial endocarditis. Used in actinomycosis, gingivitis, stomatitis, otitis media, pharingitis, sinusitis, purulent meningitis, cholecystitis, angina, scarlatina, pertussis, bacterial and amebic dysentery, brucellosis, tularemia, epidemic typhus and relapsing fever psittacosis, gonorrhea, syphilis, in infectious diseases of genitourinary tracts, skin and tissues infections, and other infectious diseases caused by microorganisms that are sensitive to this antibiotic. Tetracycline may be used for the prevention of infectious complications in surgical patients.

special indication

Prescription and treatment of Thymalinum should be under the control of immunologic indices.

special warning

Not established

Dosage and method of administration

Contents of the bottle should be diluted in 1-2 ml of isotonic sodium chloride solution and mixed shaking slightly avoiding foaming to obtain even suspension.

Should be injected deep intramuscularly (avoid getting into blood vessels).For adults the drug is prescribed as 0,005—0,02 g (5—20 mg) daily (0,03—0,1 g for a course). For children under one year of age the drug is recommended to be injected as 0,001 g (1 mg), aged 1 to 3 years — 0,001—0,002 g (1—2 mg), aged 4 to 6 years — 0,002—0,003 g (2—3 mg), aged 7 to 14 years — 0,003—0,005 g (3—5 mg) for 3—10 days depending on disorder expression of immunity.

If required, the repeated course is recommended in 1—6 months.

For preventive therapy for adults should be used as 0,005—0,02 g daily, for children— 0,001—0,005 g daily for 3—5 days.

overdosage

Cases of overdosage have not been described.

In animal experiments chronic injecting in high doses causes involution of thymus.

safety measures

With care it is used for the patients with recurrent allergoanamnesis.

Side effects

Components of the drug may cause allergic reactions.

Contraindications

Hypersensitivity to ingredients of the product. Pregnancy, lactation.

Interactions with other medicinal preparations

May be used in combination with biostimulants and immunostimulants, Rifampicin, Isoniazid, glucocorticoid drugs.

Shouldn’t be used simultaneously with T-activinum, Thymactidum, Thymogen, Thymoptin which are of the analogous effect.

The form of release

Lyophilized powder to prepare solution for injections in bottles (a bottle contains 10 mg). A pack contains 5 or 10 bottles. A pack contains 5 bottles with 5 ampoules of 2 ml 0,9% isotonic sodium chloride solution.