Project Description

Natrii nucleinas

(capsules 0.1 g)

international nonproprietary name

Sodium nucleinate

Ref

BP-0133

Pharmacotherapeutic group

Immunomodulators

Composition of the preparation

1 capsule contains 100 mg of sodium nucleinate.

1 vial (single-dose pack) contains 500 mg of sodium nucleinate.

Pharmacological action

Pharmacodynamics

Action of sodium nucleinate appears in induction of leukocytic reaction, stimulation of bone marrow performance, intracellular and nucleic metabolism, stimulation of T- and B-system and phagocytic immunity system, especially at immunodeficiency and antitoxic resistance of organism and diminution of toxic immunosupression properties of cytostatic agents (cyclophosphan), antibiotics, hormones and cardiac glycosides; tissue regeneration at dystrophies and ulcerative defects, including trophic ulcer of limbs, ulcerative diseases of stomach and duodenum, ulcerative colitis and other processes at which defects of immune system are registered; prevention or reduction of intensity of allergic reactions.

Pharmacokinetics

Pharmacokinetics ofsodium nucleinate is not described.

Indications 

Sodium nucleinate is used in complex therapy as an immunomodulatory drug: at diseases accompanied by development of immunodeficiency (disease of upper air passages and various pneumonii, tuberculosis, rheumatism, ulcerative diseases of gastroduodenal region, herpetic keratitis, kidney and liver diseases, psychic disorders, etc.); at dystrophies and ulcerative processes, including tapetochoroidal dystrophy of retina; at parodontosis; at increased exercise stress (sportsmen) and work under extremal conditions; for increase of activity of low intensity immunogene vaccine and vaccination of people with immunodeficiency; for prophylaxis of postsurgical bacteritic complications and amelioration of wound healing; for treatment and prophylaxis of bacterial and professional intoxications; for regeneration of immune state at persons of  elderly and senile age.

special indication

Not established

special warning

Not established

Dosage and method of administration

Sodium nucleinate is used for intake after meal. Single dose is 1-2 g in 2-4 intakes during the period from 2 weeks to 3 months and more.

Children are prescribed in the following doses: at the age under one year – 0.005 -0.01 g per intake, from 2 to 5 years – 0.015 – 0.05 g per intake, from 5 to 7 years – 0.1 g, from 8 to 14 years – 0.2 – 0.3 g 3-4 times a day.

Persons of elderly and senile age take the drug two times a year, in spring and in autumn by 1-1.5 g a day during 2-3 weeks with polyvitamins.

In case of leucopenia adults are prescribed by 0.1-0.2 g four times a day during the period of 10 days and more (depending on the clinical course). Sportmen are prescribed by 1-1.5 g per day in 2-3 intakes during the contest.  As preventive measures for occupational hazard the drug is intaken in daily doses 1-1.5 g in courses of 2-3 weeks, 1-2 times a year. Sodium nucleinate therapy is conducted under the control of immune state.

overdosage

No effects of overdose while using the drug are detected.

safety measures

Not established

Side effects

Not described until now .

Contraindications

No contraindictions to using the preparation is revealed.

Small nuclear ribonucleic acid (RNA) and its sodium salt (sodium nucleinate) are natural preparations with physiological mechanism of action entering all the foodstuffs of herbal and animal origin, nontoxic, with no restrictions and incompatibility with other drugs.

Interactions with other medicinal preparations

At using the drug in cases of acute bacterial infections sodium nucleinate is used together with antibiotics.

Undesirable drug interaction at prescription of sodium nucleinate together with other drugs is not described.

The form of release

Capsules containing 100 mg. 10 capsules being in contour cellular packs. 3 contour cellular packs in a parcel.