international nonproprietary name
Ascorbic acid. Rutin.
Ascorbic acid. Rutoside.
Vitamins. Ascorbic acid in combination with other preparation. Capillarotonic preparations.
Composition of the preparation
50mg of ascorbic acid and 50mg of rutin per 1 tablet.
Combinedpreparation. Restore the deficit of C and P vitamins.
Ascorbic acid fills the shortage some vitamin C in an organism, renders metabolic, anti-oxidant action, participates in regulation of a carbohydrate exchange, coagulability of blood, regeneration of tissues and metabolism of iron, promotes increase of resistibility of an organism
Rutoside concerns to vitamin of group P. Eliminating the raised permeability of capillaries, strengthens a vascular wall, reduces its puffiness and an inflammation. Possesses antiaggregant action that promotes improvement of microcirculation.
After intake the ascorbic acid is absorbed mainly in a lean gut. Absorption decreases at the use of fresh fruit and vegetable juices, alkaline drink. In 30 minutes after reception the maintenance of an ascorbic acid noticeably increases and turns to a hydroascorbic acid. Further gets through cellular membranes inside of cells where it is quickly restored. Collects basically inside of cells in three forms: ascorbic, dihydroascorbic acids and ascorbigen (the connected ascorbic acid). Easily gets into leukocytes, platelets, and then – in other tissues of organism; it is deposited in a back share of hypophysis, a bark of adrenal glands, eye epithelium, interstitial cells seed glands, ovaries, liver, brain, spleen, pancreas, lungs, kidneys, wall of intestines, heart, muscles, thyroid gland. Gets through the placenta. Mainly metabolized in a liver (up to 90 %) in deoxyascorbic acid and further in oxaloacetic and diketo-gulonic acids. Not changed ascorbic acid and metabolites are allocated with urine, and also with faeces, sweat and chest milk. At application of high dozes when concentration in plasma reaches more than 1,4 mg/dl, deducing sharply increases.
Rutoside helps to transport and deposition of an ascorbic acid. At intake the maximal concentration rutoside in blood is reached through 1-4 hours. It is allocated in the form of metabolites and in not changed form, mainly with bile, in lesser degree – with urine. The period semiejection is 10-25 hours.
Hypo- and avitaminosis of ascorbic acid and routine; composed of complex therapy at varicose veins with painful and edematic syndromes, superficial thrombophlebitis, trophic infringements and ulcers, chronic venous insufficiency; haemorrhagic diathesis; at defeats of the capillaries caused by application of anticoagulants and salicylates as preventive and medical grugs.
Pregnancy and lactation: Application of a preparation is possible at pregnancy and during a lactation under indications. With care appoint in I a trimester of pregnancy.
The preparation does not render influence on ability to drive the car and potentially dangerous mechanisms.
Dosage and method of administration
The preparation should be used after the meal.
For treatment of the adult prescripts on 1 tablet 2-3 times per day; for children over 3 years on 1 tablet 2 times per day are more senior.
As preventive drugs 2 times per day are recommended to adults on 1 tablet; to children over 3 years on 1 tablet of 1 times per day are more senior.
Duration of treatment of 3-4 weeks depending on character of disease and efficiency of treatment.
Symptoms:Headache, inflow, increase of excitability of the central nervous system, sleeplessness, infringements of gastrointestinal tract (pain in a stomach, a nausea, vomiting, a diarrhea), clotting, depressing of insular function of a pancreas (hyperglycemia, glycosuria), hyperoxaluria, nephrolithiasis, damage of glomerular function of kidneys.
Treatment: preparation intake should be stopped. Symptomatic therapy should be provided.
With care should be prescripted in case of glucose 6-phosphate dehydrogenase deficit, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, oxalosis, urolithic illness.
With care should be prescripted in case of diabetes and illnesses of kidneys.
In case of long preparation intake (more than 4 weeks) it should not be prescribed simultaneously with intimate glycosides, antihypertensive drugs and not-steroid anti-inflammatory drugs because of strengthening their action.
In case of long preparation intake it is necessary to supervise function of kidneys, level of arterial pressure and concentration of glucose in blood.
Allergic reactions (skin eruption), dyspeptic disorders (a nausea, vomiting, pains in a stomach, diarrhea), increase of arterial pressure, sleep disturbances, headache.
Increased individual sensitivity to components of a preparation. Increased coagulability of blood, thrombophlebitises, propensity to thromboses.
Interactions with other medicinal preparations
The ascorbic acid raises a level in blood salicylates,ethinyl estradioles, benzylpenicillin and tetracyclines, reduces a level of oral contraceptives. Improves absorption in intestines of iron preparations. Accelerates deducing ethyl spirit, amphetamine and tricyclic energizers. Reduces efficiency of heparin and indirect anticoagulants. Reduces therapeutic action of isoprenaline and neuroleptics – phenothiazine derivatives. In high dozes raises deducing of mexiletin by kidneys.
Preparations of quinoline line, calcium chloride, salicylates, glucocorticoides at long application exhaust stocks of an ascorbic acid. Barbiturates and primidon raise deducing an ascorbic acid with urine.
The form of release
Per 50 tablets per vial.