Project Description

Remantadine

(tablets 0,05 g) Tabuletae Remantadini 0,05

international nonproprietary name

Rimantadine.

Ref

BP-0116

Pharmacotherapeutic group

Antiviral agents.

Composition of the preparation

1 tablets contains rimantadine 50 mg.

Pharmacological action

Pharmacodynamics

Remantadine is effective in relation to virus stains of influenza А (especially of type A 2). It is active in relation to vernal encephalitis virus (Central-European and Russian spring-summer) that belongs to Flaviviridae arboviruses group. The main antiviral mechanism is inhibition of specific reproduction at early stage after the penetration of the virus into the cell and till the initial RNA translation. Pharmacological effectiveness of the preparation is provided on inhibiting the virus reproduction at the early stage of the infection process. Remantadine has an antitoxic action on influenza induced by virus В. Non effective on other SARS.

Pharmacokinetics

Remantadine is absorbed well but slowly from the gastrointestinal tract. The major part of the preparation is intensively metabolizes. The half-period from plasma is 24—36 hours. It is excreted in the urine: less then 15% of the dose — unaltered, about 20% — in the form of hydroxyl metabolites. On kidney failure the half-period increases app.twice.

Indications 

Early treatment and prophylaxis of influenza in adults and children older than 7 years old; prophylaxis of influenza in adults in the epidemic period; prophylaxis of vernal encephalitis of viral aetiology.

special indication

On treatment of patients with kidney failure it is necessary to reduce the dose.

special warning

Not established

Dosage and method of administration

As a therapeutic preparation on influenza remantadin is prescribed as follows. In adults: On the 1st day — 100 mg 3 times a day; on the 2nd and 3rd day —100 mg two times a day; on 4th and 5th — 100 mg once a day. On the 1st day the preparation may be prescribed in the dose 150 mg 2 times a day or 300 mg in the single dose. For children at the age of 7 to 10 — 50 mg 2 times a day; at the age of 11—14 — 50 mg 3 times a day; the course of treatment is 5 days.

For prophylaxis of influenza the preparation is prescribed  in the dose50 mg once a day during 10—15 days.

For prophylaxis of vernal encephalitis of viral aetiology in adults remantadine is prescribed in the dose 100 mg 2 times a day with interval of 12 hours during 3 days. In certain cases the course of treatment can last 5 days. The prophylaxis with remantadine should start immediately after the tick bite, but not later than 48 hours! For risk groups (people living or staying close to the forest zone) the prophylaxis for vernal encephalitis in the period of up to 15 days is admissible.

Remantadine is administered per os after meals with water.

overdosage

Not established

safety measures

On administration of remantadine exacerbation of chronic coexisting diseases is possible. In elderly patients with arterial hyper tension the risk of hemorrhagic stroke is high. In patients with indication to epilepsy in the anamnesis and with carried out anticonvulsion therapy remantadine may increase the risk of epileptic attack. In such cases remantadine should be prescribed in the dose up to 100 mg/day simultaneously with anticonvulsion preparations.

Side effects

On administration of the preparation the following cases can occur: pains in the epigastrium, tympanitis, increased level of bilirubin in blood; headache, insomnia, nervousness, dizziness, concentration disturbances.

Contraindications

Acute liver diseases, acute and chronic kidney diseases, thyrotoxicosis, pregnancy and lactation (it is strongly recommended to stop lactation for the course of treatment); higher sensitivity to the preparation.

Interactions with other medicinal preparations

It increases the exciting effect of caffeine.

The form of release

50 mg tablets. 20 tablets in a can. 10, 20 tablets in a blister. 10 tablets in blister. 1 or 2 blisters in the package.