Project Description

Proxodolol

(solution 1% (eye drops) – 1 ml N°10 Proxodololum

international nonproprietary name

Proxodolol.

Ref

BP-0115

Pharmacotherapeutic group

Alpha- and beta-adrenolytic agents.

Composition of the preparation

1 ml of eye drops contains proxodolol 10 mg.

Pharmacological action

Pharmacodynamics

Proxodolol is nonselective b-adrenoblocker combining blocking action onto b-1,2 and a-adrenoreceptors. The preparation reduces intraocular pressure that is provided by the reduction in aqueous humor production and facilitation of its outflow. The effects starts in 15—30 minutes after instillation and its maximum is achieved in 4—6 hours. The preparation does not change the pupil diameter and eye accommodation, does not irritate the eye.

Pharmacokinetics

On local administration proxodolol penetrated rapidly through the cornea into the eye tissues. It gets into systemic blood flow in small quantities.

Indications 

Proxodolol is used for reduction of intraocular pressure on primary angle-open and angle-closed glaucoma, on secondary glaucoma, on insufficient effect after antiglaucoma operations.

special indication

Not established

special warning

Not established

Dosage and method of administration

In the beginning of the treatment proxodolol solution 1% is prescribed, and when necessary, one can switch to proxodolol solution 2%. Proxodolol solution 1% or 2% is instilled into the conjunctival sac 1—2 drops 2—3 times a day.

overdosage

Not established

safety measures

Not established

Side effects

The following case are possible: cardiac rhythm delay, reduction of systemic blood pressure (due to adrenoblocking action) and bronchospasmodic effect.

Contraindications

Instillation with proxodolol is contraindicated in patients with bronchial asthma, chronic obstructive lung diseases, heart failure, marked bradycardia.

Interactions with other medicinal preparations

The preparation can be used in combination with pilocarpine and/or clonidine drops.

The form of release

Solution 1% (eye drops). 1 ml in a drop-tube. 5 in a phial. 2, 5 or 10 drop tubes in a package or 2 drop tubes in a blister.