Project Description

Nystatin

(ointment, 100000 UNITS) Unguentum Nistatini 1000000 ED/g

international nonproprietary name

Nystatin.

Ref

BP-0095

Pharmacotherapeutic group

Antifungal drug.

Composition of the preparation

1 g of  ointment contains 100000 units of nystatin.

Pharmacological action

Pharmacodynamics

Nystatin has an antifungal, fungistatic, fungicidal action.

Nystatin relates to polyene antibiotic group. It’s structure has molecules with big quantities of double bonds, stipulating for high tropicity of agent to stearic formations of thyroplasma membrane of fungus. As a result molecule is embedded into the cell membrane with formation of a quantity of channels promoting to  uncontrolled transport of water, electrolytes and nonelectrolytes. The cell losses resistance to attacks of outside osmotic forces and is lysed. Nystatin is active to yeast-like fungus of Candida and Aspergillus generation.

Tolerance progress to nystatin of sensitive fungus is very slow.

Pharmacokinetics

At external and local administration the preparation is not absorbed through cutaneous integument or mucous membranes.

Indications 

Nistatin ointment is used at candidosis of mucous tunic of oral cavity, genital organs, gastrointestinal tract, skin.

special indication

At fungus infection of vagina it is recommended to conduct a simultaneous treatment of sexual partner. During treatment sexual contacts should be avoided.

special warning

Not established

Dosage and method of administration

At curing cutaneous mycoses and mucous membranes the ointment is applied with thin layer onto affected areas 1-2 times a day, every day within 7-10 days. Application of ointment may be combined with nistatin intake.

overdosage

Not established

safety measures

Not established

Side effects

Using of nistatin may cause nausea, vomiting, diarrhea, abdominal pains, allergic reactions such as skin itch  and appearance of skin rash, fever, febrile chill.

In such cases dose should be reduced or the drug should be temporarily withdrawn.

Contraindications

Increased individual sensitivity to the preparation.

Interactions with other medicinal preparations

At simultaneous using of nistatin with clotrymasol the activity of the latter is lowered.

The form of release

Ointment ( nistatin content – 100000 UNITS in 1 g). Gallipots containing 15, 25, 30 g or tubes containing 15, 25, 30 g.