(ointment, 100000 UNITS) Unguentum Nistatini 1000000 ED/g
international nonproprietary name
Composition of the preparation
1 g of ointment contains 100000 units of nystatin.
Nystatin has an antifungal, fungistatic, fungicidal action.
Nystatin relates to polyene antibiotic group. It’s structure has molecules with big quantities of double bonds, stipulating for high tropicity of agent to stearic formations of thyroplasma membrane of fungus. As a result molecule is embedded into the cell membrane with formation of a quantity of channels promoting to uncontrolled transport of water, electrolytes and nonelectrolytes. The cell losses resistance to attacks of outside osmotic forces and is lysed. Nystatin is active to yeast-like fungus of Candida and Aspergillus generation.
Tolerance progress to nystatin of sensitive fungus is very slow.
At external and local administration the preparation is not absorbed through cutaneous integument or mucous membranes.
Nistatin ointment is used at candidosis of mucous tunic of oral cavity, genital organs, gastrointestinal tract, skin.
At fungus infection of vagina it is recommended to conduct a simultaneous treatment of sexual partner. During treatment sexual contacts should be avoided.
Dosage and method of administration
At curing cutaneous mycoses and mucous membranes the ointment is applied with thin layer onto affected areas 1-2 times a day, every day within 7-10 days. Application of ointment may be combined with nistatin intake.
Using of nistatin may cause nausea, vomiting, diarrhea, abdominal pains, allergic reactions such as skin itch and appearance of skin rash, fever, febrile chill.
In such cases dose should be reduced or the drug should be temporarily withdrawn.
Increased individual sensitivity to the preparation.
Interactions with other medicinal preparations
At simultaneous using of nistatin with clotrymasol the activity of the latter is lowered.
The form of release
Ointment ( nistatin content – 100000 UNITS in 1 g). Gallipots containing 15, 25, 30 g or tubes containing 15, 25, 30 g.