(coated tablets, 500000 UNITS) Nystatinum
international nonproprietary name
Composition of the preparation
1 coated tablet contains 500000 units of nystatin.
The agent of eye ointment Nucleavir is cyclocitidinehydrophosphate, synthetic analogue of purine nucleoside that is active to the human herpes viruses, including Herpes simplex of types 1 and 2, virus Varicella Zoster. The medication is effective in case of the pathogen resistance to acyclovir and phosphonoacetic acid. It has a direct virus-inhibitory action providing a complete blockade of the virus in the pathologic nidus.
The medication provides a rapid arresting of inflammation and improvement of the visual organ functions: reduction in number of infiltrations in the cornea, acceleration of ulceration epithelization and oxyopia have been clinically proved. The eye ointment Nucleavir reduces ophtalmalgia, lacrimation, conjunctiva reddening, eyelid oedema. It reduces the possibility of dissemination and prevents the formation of new niduses, as well as reduces the risk of development of severe complications of herpetic eye infection.
The medication is effective in mono- or combined therapy of superficial or deep types of herpetic eye lesion.
On using the eye ointment Nucleavir the agent (cyclocitidinehydrophosphate) practically does not get into the systemic blood flow. The therapy concentration in eye tissues is achieved on single application.
Nistatin is used at candidosis of mucous tunic of oral cavity, genital organs, gastrointestinal tract, skin.
With the aim of prophylactics nistatin is prescribed for prevention of candidosis for long-term treatment with antibacterial agents, especially for emaciated and weakened patients.
Direction for Use and Dosage Schedule
At fungus infection of vagina it is recommended to conduct a simultaneous treatment of sexual partner. During treatment sexual contacts should be avoided.
Dosage and method of administration
Nistatin is taken irrespective of food intake.Nistatin tablets are swallowed without chewing.
Adults are prescribed in dosage of 500000 UNITS 3-4 times a day. Daily dose of preparation is from 1500000 to 3000000 UNITS. At generalized candidosis daily dose may be increased to 4000000-6000000 UNITS.
Children under 1 year are prescribed in dosage of 100000-125000 UNITS 3-4 times a day, from 1 year to 3 years – in dosage of 250000 UNITS 3-4 times a day, over 13 year – in dosage of 250000-500000 UNITS 3-4 times a day.
Duration of treatment course is 10-14 days. If necessary, the course of medical treatment may be repeated in a week.
Using of nistatin may cause nausea, vomiting, diarrhea, abdominal pains, allergic reactions such as skin itch and appearance of skin rash, fever, febrile chill.
In such cases dose should be reduced or the drug should be temporarily withdrawn.
Increased individual sensitivity to the preparation, compromised liver function, pancreatitis.
gastric and duodenal ulcer, pregnancy, lactation (it is required to inhibit breast-feeding).
Interactions with other medicinal preparations
At simultaneous using of nistatin with clotrymasol the activity of the latter is lowered.
The form of release
Coated tablets, 500000 UNITS. 20 tablets in gallipots. 10 tablets in contour cellular packs. 2 contour cellular packs in a packet.