Project Description

Ampicillin trihydrate (tablets 0,25 g)

– Tabulettae Ampicillini trihydratis 0,25

international nonproprietary name





Pharmacotherapeutic group

Antibiotic, semisynthetic penicillin.

Composition of the preparation

1 tablet contains 250 mg of Ampicillin trihydrate.

Pharmacological action


Ampicillin trihydrate – an antibiotic of semisynthetic penicillins family. Possesses antibacterial (bactericidal) action. It is active in relation to a wide spectrum of gram-positive (a-and b -hemolytic streptococcuses, Streptococcus pneumoniae, Staрhylococcus spp., except for the strains producing a penicillinase, Bacillus anthracis, Clostridium spp., Enterococcus spp.) and gram-negative (Haemophilus influenzae, Neisseria meningitidis, Neisseria gonorrhoеae, Salmonella spp., Proteus mirabilis, Listeria monocytogenes, Shigella spp., Escherichia coli, Bordetella pertussis) microorganisms. It is destroyed by penicillinase and consequently does not act on penicillinase-generating strains of pathogenic organisms.


40-60 % of the administrated dose is absorbed in gastrointestinal tract. The maximal concentration in blood is reached in 1,5-2 h after intake. Penetrates into tissues and biological liquids of an organism. It is not destroyed in acidic medium of stomach. It is eliminated mainly by kidneys in not changed form. In urine the high concentration of not changed antibiotic are formed. It is partially excreted with bile, in nursing mothers – with milk. At repeated introductions does not cumulate, that enables to apply Ampicillin trihydrate for a long period.


Ampicillin trihydrate is administrated at pneumonias, bronchopneumonias, abscesses of lungs; peritonitis; sepsis; angina; infections, including mixed, urinary and bile-excreting tracts (pyelitis, pyelonephritis, cystitis, cholangitis, cholecystitis); infections of gastrointestinal tract, including salmonellosis carriage; infections of soft tissues and other diseases caused by sensitive to action of the antibiotic microorganisms.

special indication

During Ampicillin trihydrate treatment the regular control of function of liver, kidneys and peripheric blood pictures is necessary. At function of kidneys disorders the correction of dosage regimen in conformity with creatinine clearance value is required to patients. Toxic action on the central nervous system is possible at indication of high doses of the preparation for patients with a renal failure.

Antisensitizers are simultaneously administrated at bronchial asthma, hay fever and other allergic conditions. At hepatic failure Ampicillin trihydrate is used under the control of functional liver condition.

special warning

Not established

Dosage and method of administration

Ampicillin trihydrate is administrared per orally irrespective of food intake. The single dose for adults is 0,5 g, daily – 2-3 g. Children in the age elder than 1 month is indicated in daily dose of 100 mg/kg. The daily dose is divided into 4-6 intakes. Duration of treatment is established individually depending on severity and form of disease (from 5-10 days up to 2-3weeks and more).


Signs:shown by toxic action on the central nervous system (especially at patients with renal failure).

Treatment:symptomatic (maintenance of the vital functions).

safety measures

Not established

Side effects

Allergic reactions (urticaria, erythema, Quincke’s edema, rhinitis, conjunctivitis, rare – fever, joint pains, eosinophilia, extremely rare – anaphylactic shock), nausea, vomiting, intestinal dysbacteriosis, colitis caused by С. difficale, candidiasis of oral cavity, vaginal candidiasis.


The high individual sensitivity (including to other penicillins, cephalosporins, carbapenems), infectious mononucleosis, serious failure of liver function, thoracal feeding (for the period of treatment it is necessary to stop).

Interactions with other medicinal preparations

Ampicillin trihydrate reduces effect of oral contraceptives, increases effect of anticoagulants, antibiotics aminoglycoside types. Allopyrinol increases probability of dermal eruption. Probenecid at simultaneous administration with Ampicillinum reduces canalicular secretion of the last, therefore concentration of Ampicillinum in blood plasma increases and the risk of toxic action development increases.

The form of release

Tablets of 250 mg. 24 tablets in containers, 10, 20, 24, 30 tablets in blisters, 6, 10 tablets in blisters withoutcells.